Table 1 Diagnostic Choices and Their Potential Treatment Focuses on of Specific DCM Causes DCM; p38 signaling in DCM; gene modification in sufferers with truncating variantsToxic (alcoholic beverages/medication, cardiotoxic chemotherapy)Complete background of toxin publicity; probability for urine toxicology screenDisease onset during/after toxin exposure; regression or resolution after withholdingNo specific focuses on: withholding or reducing exposure; usage of cardioprotective realtors in anthracycline toxicity (dexrazoxane)InflammationEMB, bloodstream sampling (eg, sIL2\R, CRP, galectin\3), CMRImmune cell infiltration in EMB, elevated T2\signal, elevated CRP/ESRPro\inflammatory pathways (eg IL\1)Autoimmune diseaseEMB, blood sampling, imaging, autoantibody display, presence of extracardiac featuresPresence of swelling and positive autoantibody titersAuto\antibodies (eg, (1)\AABs)ViralEMBCardiotropic disease presence having a viral weight 500?copies/g DNAVirus and subsequent cardiac inflammationElectrical12\lead ECG, ambulatory ECG monitoring 10?000 to 25?000?PVCs/d; (supra)ventricular tachycardiaAbnormal electrical pathwaysPeripartum(history of) PregnancyDisease onset during pregnancy up to 6?mo postpartumCleaved 16?kDa N\terminal fragment of prolactinCardiac metabolismBlood, cells and/or urine metabolomicsElevated acylcarnitines, upsurge in ketone bodiesMultiple strategies possible interfering using the metabolic substrate change (mainly involving mitochondrial pathways)Cardiac fibrosisEMB, CMR, bloodIncreased CFV; midmyocardial LE; increased fibrosis blood markersRAAS\pathway; angiotensin II\galectin\3\interleukin\6 axis; matricellular proteins; syndecan\4\osteopontin\lysyl oxidase\like axis Open in another window AAB indicates autoantibodies; CFV, collagen small fraction quantity; CMR, cardiac magnetic resonance; CRP, C\reactive proteins; DCM, dilated cardiomyopathy; EMB, endomyocardial biopsy; ESR, erythrocyte sedimentation rate; ICD, implantable cardiac defibrillator; LE, late enhancement; PVC, premature ventricular complicated; RAAS, renin\angiotensin\aldosterone program; WES, entire exome sequencing

Table 1 Diagnostic Choices and Their Potential Treatment Focuses on of Specific DCM Causes DCM; p38 signaling in DCM; gene modification in sufferers with truncating variantsToxic (alcoholic beverag... Read More