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Fix of DNA interstrand crosslinks (ICLs) predominantly involves the Fanconi anemia (FA) pathway and homologous recombination (HR). CL-V8B will not impact the effectiveness and stabilization of replication forks. Nevertheless, stalling from the forks in response to replication tension is observed fairly rarely, which implies an impairment of the signaling mechanism. Publicity of CL-V8B to crosslinking…