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Allosteric modulators are an appealing method of achieve receptor subtype-selective targeting of G protein-coupled receptors. way that correlates with orthosteric ligand efficiency and stimulus-response coupling from the receptor (8). Additionally, BQCA will not engender pathway-biased signaling by orthosteric agonists on the M1 mAChR (8). These properties make BQCA an extremely useful chemical device with which…