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Retroviral capsid recognition by Cut5 blocks successful infection. green monkeys) or HIV-2Fishing rod (which originated by cross-species transmitting of SIVsm [75]). On the other hand, rhTrim5TFP limited HIV-1nl4.3, SIVsmE041, SIVsmE543-3, SIVagmTAN-1 also to a lesser level, HIV-2ROD. Just the rhesus macaque isolate, SIVmac239, was resistant to both alleles. Hence, while both alleles are useful, the…