Tag: CD22

Purpose Pre-clinical studies can help guide the selection of agents and regimens for clinical testing. NOD/SCID/chainnull mice reconstituted with human hematopoietic cells and the impact of treatment on human hematopoiesis was evaluated. Results The dose-intensive regimen resulted in significant decreases in growth of human-glioblastoma xenografts. When this regimen was administered to mice made up of…