Tag: Enzastaurin ic50
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Supplementary MaterialsSupplementary Information srep22784-s1. decreased the expression of HIF-1 target genes
Supplementary MaterialsSupplementary Information srep22784-s1. decreased the expression of HIF-1 target genes and reduced glycolysis in normoxic cancer cells. NECAB3 mutants that binds Mint3 but lacks an intact monooxygenase domain also inhibited HIF-1 activation. Inhibition of NECAB3 in cancer cells by either expressing shRNAs or generating a dominant negative mutant reduced tumourigenicity. Taken together, the data…