Tag: Igfbp1

  • Steroidogenic factor-1 (SF-1/Ad4BP/NR5A1) takes on a major part in regulating steroidogenic

    Steroidogenic factor-1 (SF-1/Ad4BP/NR5A1) takes on a major part in regulating steroidogenic enzymes. of CYP11B2. Nevertheless, in H295R/TR/SF-1 cells without doxycycline treatment, both CYP11B1 and CYP11B2 mRNAs had been significantly decreased, recommending that both enzymes need a minimal degree of SF-1 for basal manifestation. In conclusion, SF-1 overexpression significantly inhibited CYP11B2 manifestation and reduced aldosterone creation.…