Tag: KX2-391

  • Level of resistance to the HER2-targeted antibody trastuzumab is a significant

    Level of resistance to the HER2-targeted antibody trastuzumab is a significant clinical concern in the treating HER2-overexpressing metastatic breasts malignancy. on trastuzumab treatment. 1. Intro Trastuzumab (Herceptin; Genentech, SAN FRANCISCO BAY AREA, CA) is certainly a humanized monoclonal antibody against an epitope in the extracellular area from the HER2 receptor tyrosine kinase proteins [1]. HER2…

  • Melanocyte-stimulating hormone (MSH)-induced activation of the cAMP-response element (CRE) via the

    Melanocyte-stimulating hormone (MSH)-induced activation of the cAMP-response element (CRE) via the CRE-binding protein in hypothalamic cells promotes expression of TRH and thereby restricts food intake and increases energy expenditure. and glucose-induced CRE activity, suggesting a role for AMPK/CRTC-2 in glucose-induced CRE activation. Accordingly, small interfering RNA-induced down-regulation of CRTC-2 expression decreased glucose-induced CRE-dependent reporter activation.…

  • CBA/Ca mice contaminated with 5 104 AS-parasitized erythrocytes experience severe but

    CBA/Ca mice contaminated with 5 104 AS-parasitized erythrocytes experience severe but self-limiting infections of relatively short duration. those comprising mature (trophozoite and schizont) parasites, was shown by immunofluorescence in APP and the immunoglobulin G (IgG)-comprising portion thereof. Unfractionated APP (from AS-infected mice), as well as its IgG portion, specifically mediated the opsonization and internalization of…