Tag: Natamycin reversible enzyme inhibition
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Supplementary Materialssupplemental material 41419_2018_870_MOESM1_ESM. pathways, as well as increased cleavage of
Supplementary Materialssupplemental material 41419_2018_870_MOESM1_ESM. pathways, as well as increased cleavage of OPA1, a mitochondrial protein that promotes mitochondrial fusion and regulates apoptosis. Consistent with these observations, transmission electron microscopy analysis indicated that NS1619 and DHEA increased mitochondrial fission. OPA1 cleavage and cell death were inhibited by ROS scavengers and by siRNA-mediated knockdown of the mitochondrial…