Tag: Rabbit Polyclonal to COMT

Free of charge histones, not nucleosomes, are cytotoxic and so are degraded by FSAP in serum to safeguard against cytotoxicity. of cultured cells in vitro. Upon incubation of serum with histones, endogenous FSAP was triggered and degraded histones, which also avoided cytotoxicity. Notably, histones within nucleosome complexes weren’t cytotoxic, whereas DNA digestive function restored cytotoxicity.…