Tag: TMEM47

Although chromatin condensation is among the hallmarks of apoptosis, its relationship with DNA fragmentation continues to be controversial. nucleoplasmin is usually tyrosine-dephosphorylated and excluded from condensed chromatin during apoptosis. Inhibition of tyrosine dephosphorylation prevents chromatin condensation but will not stop DNA fragmentation. A phosphorylation-mimicking mutant, Y124E, delays the event of chromatin condensation during apoptosis inside…